Imidazole → HCID 12786200, compound

Participants

Reaction Steps

To a stirred mixture of 24.5 g. (55.6 mmoles) of 1-iodo-4-hydroxy-4-methyl-trans-1-octene (Example 605), 13.6 g. (200 mmoles) of imidazole, and 75 ml. of dimethylformamide is added 10.9 g. (100 mmoles) of chlorotrimethylsilane. After standing overnight the mixture is poured into 250 ml. of hexane. The mixture is washed thoroughly with water followed by brine and dried over magnesium sulfate. After removal of the solvent, the product is distilled to give a colorless liquid, boiling point 67.5°-68° (0.07 mm.).

Provenance & Evidence