HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 3,3,3-trifluoro-1-phenylpropan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | 3'-(Trifluoromethyl)acetophenone | HCID 67682 | — |
| Reactant | 1-(3-Chloro-4-fluorophenyl)-N,N-dimethylhydrazine-1-carboxamide | HCID 12789936 | — |
| Product | 3,3,3-trifluoro-1-phenylpropan-1-one | HCID 9834155 | — |
Reaction Steps
To a solution of 10 grams of 4,4-dimethyl-2-(3-chloro-4-fluorophenyl)semicarbazide in 200 milliliters of benzene was added 8.1 grams of m-trifluoromethylacetophenone. This mixture was stirred and heated at reflux for 18 hours. The solvent was removed and the residue purified by silica chromatography to give 13 grams (75.1 yield) of 2-trifluoromethylacetophenone, 4,4-dimethyl-2-(3-chloro-4-fluorophenyl) semicarbazone as an amber syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04108399 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-d744f67d3ceb4f47bbd6b67854a7e5e9 |
| Source note | uspto-grants-1978_08 |