HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → Nicotinonitrile, 1,2-dihydro-2-oxo-1,4,6-trimethyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Acetylacetone | HCID 31261 | — |
| Reactant | 2-Cyano-N-methylacetamide | HCID 80622 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Nicotinonitrile, 1,2-dihydro-2-oxo-1,4,6-trimethyl- | HCID 46479 | 77.4% |
Reaction Steps
N-methyl cyanoacetamide (113 g., 1.15 mole), 2,4-pentanedione (115 g., 1.15 mole), piperidine (11.5 ml.) and anhydrous ethanol 250 ml. are refluxed with stirring for 3 hours. The mixture is allowed to stand overnight at room temperature and the white crystalline precipitate is collected by filtration to give 1-methyl-3-cyano-4,6-dimethylpyrid-2-one, 144 g. (77.4% yield), mp. 202°-205° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04108630 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-edb66d2e93904870bb473a05a9d01b1e |
| Source note | uspto-grants-1978_08 |