HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 1-(2-Ethylhexyl)-3-cyano-4,6-dimethylpyrid-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Acetylacetone | HCID 31261 | — |
| Reactant | 2-cyano-N-(2-ethylhexyl)acetamide | HCID 4590704 | — |
| Product | 1-(2-Ethylhexyl)-3-cyano-4,6-dimethylpyrid-2-one | HCID 20312180 | 60% |
Reaction Steps
A mixture of N-(2-ethylhexyl)cyanoacetamide (201.5 g., 1.0 mole), 2,4-pentanedione (100 g., 1.0 mole), piperidine (10 g.) and 2-B-ethanol 300 ml. is refluxed for 24 hours, cooled to room temperature and the solid precipitate is collected by filtration to give 155 g. (60% yield), mp. 84°-89° C. The solid when recrystallized from petroleum ether/benzene has a mp. 89°-90° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04108630 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-21316e8dd7b04c01b78e101ae13ed5b2 |
| Source note | uspto-grants-1978_08 |