反应详情

To 2.9 g (0.01 mol.) of N-t-butoxycarbonyl-2-acetoxyglycine n-butyl ester in 10 ml. of dioxane was added a solution of sodium phenolate prepared from 0.94 g. of phenol and 0.54 g. of sodium methoxide in 15 ml. of dioxane After refluxing for 2 hours, the solvent was evaporated in vacuo and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed with cold 10% aqueous sodium hydroxide, dried (MgSO4) and concentrated to yield the title compound as an oil.

1. customprepared from 0.94 g
2. customthe solvent was evaporated in vacuo
3. dissolutionthe residue was dissolved in ethyl acetate
4. washThe ethyl acetate solution was washed with cold 10% aqueous sodium hydroxide
5. dry with materialdried (MgSO4)
6. concentrationconcentrated