Dichloromethane → Butyl α-[[(1,1-dimethylethoxy)carbonyl]amino]-2-furanacetate

Participants

Reaction Steps

A solution of 1.6 g. (0.006 mol.) of N-t-butoxycarbonyl-2-acetoxyglycine n-butyl ester and 0.7 g. (0.01 mol.) of redistilled furan in 75 ml. of methylene chloride was cooled to -78° and four drops of boron trifluoride etherate was added with stirring. The reaction mixture was warmed to room temperature and left for 3 hours. Chromotography on silica gel with methylene chloride and methylene chloride containing increasing amounts of ethyl acetate gave the title compound.

Provenance & Evidence