HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → HCID 20312589, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | N-Methylformanilide | HCID 66737 | — |
| Reactant | Ethyl 2-(acetylamino)-4-methylthiophene-3-carboxylate | HCID 290215 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Product | HCID 20312589 | HCID 20312589 | — |
Reaction Steps
A mixture of 22.7 parts of 2-acetylamino-3-ethoxycarbonyl-4-methylthiophene, 261 parts of N-methylformanilide and 28.4 parts of phosphoryl chloride is stirred for 90 minutes at 90° - 95° C. 300 Parts of a 4N aqueous solution of sodium acetate are added and the mixture stirred for 10 minutes at 90° C. The oily solid is separated from the liquid and crystallised from ethanol to give 2-acetylamino-3-ethoxycarbonyl-4-methyl-5-formylthiophene (m.pt 174° - 176° C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04108867 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-b1b86ab17e72454db1ac21e83ff156ee |
| Source note | uspto-grants-1978_08 |