2-(2-Methoxyethyl)-2-imidazoline hydrochloride → 2-(2-Methoxyethyl)-4,5-dihydro-1H-imidazole

100 Parts of 6N sodium hydrochloride in a suitable reaction vessel are cooled to 5° C with an ice-water bath and 22.7 parts of the 2-(2-methoxyethyl)-2-imidazoline hydrochloride of Example 2 are added to the cold solution. An oil separates. The contents of the vessel are transferred to a separatory vessel and the aqueous phase is extracted four times with 30 parts of reagent grade tetrahydrofuran. The combined tetrahydrofuran extracts are dried over anhydrous potassium carbonate for 15 hours. The potassium carbonate is then filtered off and the tetrahydrofuran solution is distilled to yield 14.0 parts of 2-(2-methoxyethyl)-2-imidazoline.

1. customThe contents of the vessel are transferred to a separatory vessel
2. extractionthe aqueous phase is extracted four times with 30 parts of reagent grade tetrahydrofuran
3. dry with materialThe combined tetrahydrofuran extracts are dried over anhydrous potassium carbonate for 15 hours
4. filtrationThe potassium carbonate is then filtered off
5. distillationthe tetrahydrofuran solution is distilled

ORD record

ord-71920d345db4468fa2610cd0b5f7e9e4

Source dataset

uspto-grants-1978_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04108883