Ammonium Hydroxide → HCID 12805578, compound

Participants

Reaction Steps

The product of Example 3 (1.04 g.) is treated for 1 hour, under an argon blanket, with a solution of 2.4 ml. of water and 1.6 ml. of concentrated ammonium hydroxide solution. The reaction mixture is diluted with water, extracted twice with ethyl acetate, the aqueous phase is acidified with concentrated hydrochloric acid and extracted into ethyl acetate. The ethyl acetate extract is dried over magnesium sulfate and concentrated in vacuo. The product, 1-[(3-mercaptopropanoyl)amino]cyclopentane carboxylic acid, is crystallized from ethyl acetate and recrystallized from acetonitrile, yield 343 mg., m.p. 175°-176°.

Provenance & Evidence