Ammonium thiocyanate → (3,5-Dimethyl-1H-pyrazol-4-YL)thiourea

HRID 2420070Notes

Reaction equation

HRID 2420070 reaction equation
Cl.[CH3:2][C:3]1[C:7]([NH2:8])=[C:6]([CH3:9])[NH:5][N:4]=1.[S-:10][C:11]#[N:12].[NH4+]>O>[CH3:2][C:3]1[C:7]([NH:8][C:11]([NH2:12])=[S:10])=[C:6]([CH3:9])[NH:5][N:4]=1

Participants

4

Reactant 2

HCID 15666Ammonium thiocyanateHCID 203128873,5-Dimethyl-4-aminopyrazole hydrochloride

Product 1

HCID 20312848(3,5-Dimethyl-1H-pyrazol-4-YL)thioureaYield 77.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

19.0 grams (g) of 3,5-dimethyl-4-aminopyrazole hydrochloride and 19.7 g of ammonium thiocyanate are dissolved in 100 milliliters (ml) of water, and the resulting solution is heated at boiling under reflux for 6 hours. Then the solution is concentrated to about 50 ml and cooled. Thus-formed precipitate is separated by filtration, washed with a little water and dried to yield 17.0 g of 3,5-dimethyl-4-thioureidopyrazole, mp 209° to 211°.

Workup

  1. temperaturethe resulting solution is heated
  2. temperatureunder reflux for 6 hours
  3. concentrationThen the solution is concentrated to about 50 ml
  4. temperaturecooled
  5. customThus-formed precipitate
  6. customis separated by filtration
  7. washwashed with a little water
  8. customdried

Sources & evidence

ORD record
ord-9aaa991f73294c4f84d67fbde883b6e1
Source dataset
uspto-grants-1978_08
Patent number
US04108982

Reaction notes

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