HCID 20312869, compound → HCID 20312844, compound

HRID 2420072Notes

Reaction equation

HRID 2420072 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([NH:13][C:14]2[N:15](C(=O)C3C=CC=CC=3)[CH2:16][CH2:17][N:18]=2)[C:4]([CH3:27])=[N:3]1>CO>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([NH:13][C:14]2[NH:15][CH2:16][CH2:17][N:18]=2)[C:4]([CH3:27])=[N:3]1

Participants

3

Reactant 1

HCID 20312869HCID 20312869, compound

Product 1

HCID 20312844HCID 20312844, compoundYield 80.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10.0 g of 1,3-dimethyl-5-phenyl-4-(1-benzoyl-2-imidazolin-2-yl)aminopyrazole are heated to boiling in methanol under reflux for 6 hours. The solvent (methanol) is distilled off in vacuo, and the residue is twice recrystallized from isopropyl alcohol to yield 5.7 g (80.2% of theory) of 1,3-dimethyl-5-phenyl-4-(2-imidazolin-2-yl)aminopyrazole, mp 232° to 234°. The mixed melting point with the product obtained in accordance with Example 8 shows no depression.

Workup

  1. temperatureunder reflux for 6 hours
  2. distillationThe solvent (methanol) is distilled off in vacuo
  3. customthe residue is twice recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-a8c081daf6a94ee1a75a1102496f5ef1
Source dataset
uspto-grants-1978_08
Patent number
US04108982

Reaction notes

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