Formaldehyde → HCID 20312937, compound

Participants

Reaction Steps

300 ml of an aqueous solution of 30% formic aldehyde were added to a mixture of 30 g of 4-(3',4'-dichlorophenyl)-3-oxo-5,6-dihydro-1,2,4-oxadiazine, 30 g of anhydrous sodium acetate and 300 ml of dioxane and then the mixture was stirred for 2 hours at 20°-25° C and was acidified. The mixture was extracted with ethyl acetate and the extracts were dried and evaporated to dryness under reduced pressure. The residue was taken up in isopropyl ether and the mixture was vacuum filtered. The recovered solids were dried to obtain 30 g of 2-hydroxymethyl-4-(3',4'-dichlorophenyl)-3-oxo-5,6-dihydro-1,2,4-oxadiazine melting at 134° C.

Provenance & Evidence