Acetic Anhydride → HCID 20313028, compound

Participants

Reaction Steps

3.0 Grams of methyl 5-(4-nitrobenzyl)picolinate were dissolved in 150 ml. of a mixture of acetic acid and acetic anhydride (4:1). The resulting solution was added with 6.0 g of 5% palladium-carbon. Catalytic reduction was carried out at room temperature under atmospheric pressure. After 1.5 hours, the reaction solution was subjected to filtration and the filtrate was concentrated under reduced pressure. The residue was added with n-hexane to form crystals. The crystals were recrystallized from a solvent comprising a mixture of chloroform/n-hexane to obtain 1.5 g of methyl 5-(4-acetaminobenzyl)picolinate.

Provenance & Evidence