Chloroform → HCID 53743984, compound

Participants

Reaction Steps

2.1 Grams of 5-benzylpicolinic acid were dissolved in 20 ml. of chloroform. The resulting solution was then added with 1.2 g of triethylamine and 1.1 g of ethyl chlorocarbonate and thereafter with 33% ethylamine solution dropwise under ice-cooling and stirring. After 30 minutes 10 ml. of water were added thereto and the mixture was fractionated. The organic layer was washed with 10% aqueous ammonia. After drying, the solvent was distilled out. The residue was recrystallized from n-hexane to obtain 2.0 g of 5-benzyl-picolinic acid N-ethylamide as colorless crystals of a melting point of 77°~78° C.

Provenance & Evidence