Hexamethylenetetramine → 1-[(3-Phenyl-5-isoxazolyl)methyl]-3,5,7-triaza-1-azoniaadamantane bromide

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Reaction Steps

A 90 g. portion of the product of Example 1 was dissolved in 1.5 l. of chloroform and 70 g. of hexamethylenetetramine was added. The mixture was stirred at reflux temperature for 4 hours, and was filtered hot. The solids were dried under vacuum to obtain 143 g. of impure product, m.p. 159°-160°, which contained about 93 percent product and 7 percent hexamethylenetetramine.

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