HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Carboxy-3-methyl-5,6-dihydro-1,4-dithiin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 3-methyl-5,6-dihydro-1,4-dithiine-2-carboxylate | HCID 12368330 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Carboxy-3-methyl-5,6-dihydro-1,4-dithiin | HCID 600502 | — |
Reaction Steps
3-Ethoxycarbonyl-2-methyl-5,6-dihydro-1,4-dithiin (10.0 g.) is heated at reflux for eight hours in a solution of potassium hydroxide (85%; 3.60 g.) in methanol (40 ml.). The cool solution is acidified wth 10% aqueous hydrochloric acid and the precipitate is removed by filtration and dried (8.1 g.). The crude product is recrystallized from ethanol to afford 2-carboxy-3-methyl-5,6-dihydro-1,4-dithiin, m.p. 179°-180° C., dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04109006 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-70e4d169155a4e7c915561bf3de09c9b |
| Source note | uspto-grants-1978_08 |