Tetrahydrofuran → HCID 12917378, compound

Participants

Reaction Steps

In 200 ml. of anhydrous tetrahydrofuran was suspended 3.0 g. of lithium aluminum hydride and after adding slowly to the suspension with stirring a solution prepared by dissolving 14.5 g. of 2-(7-indenyloxymethyl)-4-phenylmorpholin -5-one in 100 ml. of anhydrous tetrahydrofuran, the mixture was stirred overnight at room temperature. To the reaction mixture obtained were added successively 3 ml. of water, 3 ml. of a 15% sodium hydroxide aqueous solution, and then 9 ml. of water to decompose excessive lithium aluminum hydride. Then, by treating the solution in a similar manner as in Example 7-(b), 10.6 g. of oily 2-(7-indenyloxymethyl)-4-phenylmorpholine was obtained.

Provenance & Evidence