Tetrahydrofuran → HCID 20313204, compound

Participants

Reaction Steps

In 10 ml. of tetrahydrofuran was dissolved 3.17 g. of 4-isopropyl-2-(3-methyl-1-oxo-5-indanyloxymethyl)-5-oxomorpholine and the solution was added dropwise to the suspension of 0.4 g. of lithium aluminum hydride in 20 ml. of tetrahydrofuran followed by stirring for 5 hours at room temperature. Thereafter, 0.4 ml. of water, 0.4 ml. of aqueous 15% sodium hydroxide solution, and then 1.2 ml. of water were added successively to the mixture followed by stirring for 30 minutes and then the filtrate obtained was concentrated under reduced pressure to provide 2.1 g. (yield 68.8%) of 2-(1-hydroxy-3-methyl-5-indanyloxymethyl)-4-isopropylmorpholine having a boiling point of 174°-178° C./0.5 mm.Hg was obtained.

Provenance & Evidence