NSC658448 → HCID 20311089, compound

HRID 2420211Notes

Reaction equation

HRID 2420211 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[C:7]([Cl:12])[C:6]=1[OH:13])(=O)[CH3:2].C([O-])(=O)C.[Na+]>>[CH3:2][C:1]1[O:13][C:6]2[C:7]([Cl:12])=[CH:8][C:9]([Cl:11])=[CH:10][C:5]=2[N:4]=1

Participants

3

Reactant 2

HCID 377212NSC658448HCID 517045Sodium Acetate

Product 1

HCID 20311089HCID 20311089, compoundYield 49.3%

Procedure

A mixture of 61.8 g of 2-acetylamino-4,6-dichloro-phenol and 4.12 g of anhydrous sodium acetate was heated for some minutes, obtaining a liquid slurry which was distilled under reduced pressure, by collecting the fraction distilled between 145° - 155° C at 1,4 mm Hg. The distilled oil upon standing became a solid which was crystallized from ligroin, obtaining 28 g of 2-methyl-5,7-dichloro-benzoxazole. M.P. = 110° - 113° C.

Workup

  1. temperaturewas heated for some minutes
  2. customobtaining a liquid slurry which
  3. distillationwas distilled under reduced pressure
  4. customby collecting the fraction
  5. distillationdistilled between 145° - 155° C at 1,4 mm Hg
  6. customwas crystallized from ligroin

Sources & evidence

ORD record
ord-6fc5607d555b445fb19f81bc2d984d9d
Source dataset
uspto-grants-1978_08
Patent number
US04110116

Reaction notes

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