Sulfuric Acid → HCID 53863748, compound

HRID 2420217Notes

Reaction equation

HRID 2420217 reaction equation
[CH3:1][CH:2]1[CH2:7][NH:6][C:5](=[O:8])[NH:4][C:3]1=[O:9].[C:10](OC(=O)C)(=[O:12])[CH3:11].S(=O)(=O)(O)O>>[C:10]([N:6]1[CH2:7][CH:2]([CH3:1])[C:3](=[O:9])[NH:4][C:5]1=[O:8])(=[O:12])[CH3:11]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 93556Dihydro-5-methyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 53863748HCID 53863748, compound

Procedure

In the manner described in I, 65 gm (0.5 mol) of 5-methyl-5,6-dihydrouracil and 817 gm (8 mols) of acetic acid anhydride and 2 ml of concentrated sulfuric acid were heated to boiling for ten hours with continuous distilling off of the acetic acid produced. The product, isolated after separating of the surplus acetic acid anhydride and purified by recrystallization from isopropanol, had a melting point of 111° C to 113° C. The analysis values were as follows:

Workup

  1. temperaturewere heated
  2. waitto boiling for ten hours
  3. distillationwith continuous distilling off of the acetic acid
  4. customproduced
  5. customThe product, isolated
  6. customafter separating of the surplus acetic acid anhydride
  7. custompurified by recrystallization from isopropanol

Sources & evidence

ORD record
ord-a232af47790b402a876ba72f144f58dd
Source dataset
uspto-grants-1978_08
Patent number
US04110242

Reaction notes

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