Estriol → 1,3,5(10)-Estratriene

Participants

Reaction Conditions

Reaction Steps

In a 100 cc flask, protected from light and humidity, 5.76g (0.02 Mole) of estriol are dissolved in 60 cc of anhydrous pyridine; 9.87g (0.07 mole) of nicotinoyl chloride are added and the whole shaken at 60° C for 6 hours. After cooling, the reaction mixture is poured into a liter of ice water and shaken for 15 minutes. The precipitate is dried and washed with water until neutral. Yield: 95%. The precipitate can also be extracted with chloroform or ether.

Provenance & Evidence