Piperidine → HCID 86735973, compound

Participants

Reaction Steps

14.8 g (0.03 mole) of 2α,3α-epoxy-17β-hydroxy-16β-N-methyl-piperazino-5α-androstane (Example 10) are dissolved in 168 ml (1.65 moles) of piperidine and 24 ml of water, whereafter the reaction mixture is heated in a bomb tube of 72 hours at a temperature of 140° C. After the reaction is accomplished the reaction mixture is evaporated at reduced pressure. The residue is stirred in acetonitrile, filtered and the product above the filter is heated under reflux in acetonitrile. The crystallized product is filtered and dried. Yield: 12.4 g (69.0%) of 2β-piperidino-16β-N-methyl-piperazino-3α,17β-dihydroxy-5α-androstane; m.p. 154°-156° C; [α]D25 = +84.5° (c = 1 in chloroform).

Provenance & Evidence