HCID 86735852, compound → HCID 86735974, compound

HRID 2420243Notes

Reaction equation

HRID 2420243 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C@H:8]2[CH2:25][C@@:24]3([CH3:26])[C@@H:11]([CH2:12][CH2:13][C@@H:14]4[C@@H:23]3[CH2:22][CH2:21][C@@:19]3([CH3:20])[C@H:15]4[CH2:16][C@H:17]([N:28]4[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)[C@@H:18]3[OH:27])[CH2:10][C@@H:9]2[OH:34])[CH2:4][CH2:3]1>C(Cl)(Cl)Cl>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C@H:8]2[CH2:25][C@@:24]3([CH3:26])[C@@H:11]([CH2:12][CH2:13][C@@H:14]4[C@@H:23]3[CH2:22][CH2:21][C@@:19]3([CH3:20])[C@H:15]4[CH2:16][C@H:17]([N:28]4[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)[C@@H:18]3[O:27][C:18](=[O:27])[CH3:17])[CH2:10][C@@H:9]2[O:34][C:9](=[O:34])[CH3:8])[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 86735852HCID 86735852, compound

Product 1

HCID 86735974HCID 86735974, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The compound is prepared by acylation of 2β-N-methyl-piperazino-16β-piperidino-3α,17β-dihydroxy-5α-androstane according to the method described in Example 12. Yield: 72.0% [α]D25 = +29.4° (c = 1 in chloroform).

Sources & evidence

ORD record
ord-14559dd7fccd43f29e8bd26f5d418ed5
Source dataset
uspto-grants-1978_08
Patent number
US04110326

Reaction notes

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