HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphoric Acid → 3-Methyl-2-acetylthiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Methylthiophene | HCID 11126 | — |
| Reactant | 3-Methylthiophene | HCID 12024 | — |
| Product | 3-Methyl-2-acetylthiophene | HCID 83653 | — |
| Product | 1-(4-Methyl-2-thienyl)ethan-1-one | HCID 83654 | — |
| Product | 2-Acetyl-5-methylthiophene | HCID 83655 | — |
Reaction Steps
2-Acetyl-3-methylthiophene and 2-acetyl-4-methylthiophene are prepared by acetylation of commercially-available 3-methylthiophene with acetic anhydride in the presence of phosphoric acid by the procedure of Hartough and Kosak, J. Am. Chem. Soc., 69, 3093 (1974). Using the same procedure with commercial 2-methylthiophene provides 2-acetyl-5-methylthiophene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04110342 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-a7289b853f0a430c878b4de9f53fb8f8 |
| Source note | uspto-grants-1978_08 |