Hydrochloric Acid → HCID 20311377, compound

Participants

Reaction Steps

Methyl 5-azidomethyl-2-thienylacetate (21.1 g., 0.10 mole) was dissolved in 300 ml. of tetrahydrofuran and 40 ml. of 3M hydrochloric acid was added. After heating at reflux for 6 hours the reaction mixture was cooled and the product isolated as described in Example 9 to obtain a 62% yield of oil. 1H--NMR (CDCl3), ppm. (δ): 9.0 (s, COOH), 6.85 (s, 2 aromatic-H), 4.4 (s, CH2N3), 3.75 (s, CH2COO); IR spectrum (neat, cm.-1 : 3000 (broad), 2100 (N3), 1710 (CO2H), 1680 and 1475.

Provenance & Evidence