Butyl bromide → HCID 66584541, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.0 g (3.3 mmol) 4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylate (for synthesis see example 1, section a)) in DMSO (9 ml) was treated with 461 mg (3.3 mmol) K2CO3 and 360 μl (3.3 mmol) 1-bromobutane at RT and was subsequently heated at 50° C. for 90 mins. After cooling to RT the RS was diluted with water (30 ml) and extracted with EtOAc (3×50 ml). The combined organic layers were washed with water and brine, dried over Na2SO4 and concentrated in vacuo. After CC (EtOAc/hexane 1:8) of the residue, 480 mg (1.4 mmol, 40%) ethyl 1-butyl-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylate was obtained.

Provenance & Evidence