Lawesson's reagent → HCID 86662687, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 460 mg (1.5 mmol) ethyl 1,4-dimethyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylate in toluene (10 ml) was treated with 2.4 g (5.9 mmol) Lawesson's reagent at RT, followed by heating to 120° C. for 16 h. After cooling to RT the RS was quenched with a sat. aq. Na2CO3 solution (30 ml). The mixture was then extracted with EtOAc (3×30 ml). The combined organic layers were washed with brine, dried over Na2SO4 and concentrated in vacuo. CC (EtOAc/hexane 1:4) of the residue provided 400 mg (1.2 mmol, 82%) ethyl 1,4-dimethyl-2-thioxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylate.

Provenance & Evidence