HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → N-(4-chloro-2-nitrophenyl)-4-piperidinamine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Ethyl 4-((4-chloro-2-nitrophenyl)amino)piperidine-1-carboxylate | HCID 104608 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(4-chloro-2-nitrophenyl)-4-piperidinamine hydrobromide | HCID 20385545 | 81% |
Reaction Steps
A mixture of 84 parts of ethyl 4-[(4-chloro-2-nitrophenyl)amino]-1-piperidinecarboxylate and 750 parts of a hydrobromic acid solution 48% in water is stirred and refluxed for 4 hours. The precipitated product is filtered off, washed with water and petroleum-ether, and dried, yielding 71 parts (81%) of N-(4-chloro-2-nitrophenyl)-4-piperidinamine hydrobromide; mp. 275° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04110333 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-d14bfce80f564e13a25a2bacab5bbbd7 |
| Source note | uspto-grants-1978_08 |