Acetic Acid → 1-(3-hydroxy-1-methyl-1H-indol-2-yl)ethanone

HRID 2420456Notes

Reaction equation

HRID 2420456 reaction equation
[OH:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([CH3:11])[C:3]=1[C:12](=[O:18])[CH2:13]S(C)(=O)=O.C(O)(=O)C>[Zn].C(O)C>[CH3:13][C:12]([C:3]1[N:4]([CH3:11])[C:5]2[C:10]([C:2]=1[OH:1])=[CH:9][CH:8]=[CH:7][CH:6]=2)=[O:18]

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 125113181-(3-hydroxy-1-methyl-1H-indol-2-yl)-2-(methylsulfonyl)ethanone

Product 1

HCID 47121911-(3-hydroxy-1-methyl-1H-indol-2-yl)ethanone

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 702EthanolSolvent

Procedure

A mixture of 17.0g (0.0637 mole) 1-(3-hydroxy-1-methyl-1H-indol-2yl)-2-(methylsulfonyl) ethanone, 21.0g (0.32 mole) zinc dust, 40ml glacial acetic acid and 80ml ab. ethanol was stirred vigorously and heated at 45°-50° for 1 hour. After stirring an additional hour at room temperature, the mixture was filtered through diatomaceous earth and the filter cake washed several times with fresh ethanol. The combined filtrates were condensed to 150ml and 50ml of hot water was added. Cooling yielded a green solid which was filtered, washed with cold water and recrystallized from 70% aqueous methanol to yield green needles of mpt. 119°-121°.

Workup

  1. temperatureheated at 45°-50° for 1 hour
  2. filtrationthe mixture was filtered through diatomaceous earth
  3. washthe filter cake washed several times with fresh ethanol
  4. customcondensed to 150ml and 50ml of hot water
  5. additionwas added
  6. temperatureCooling
  7. customyielded a green solid which
  8. filtrationwas filtered
  9. washwashed with cold water
  10. customrecrystallized from 70% aqueous methanol
  11. customto yield green needles of mpt
  12. custom119°-121°

Sources & evidence

ORD record
ord-bd4501ca08cf4c1cba1f943e4b5320b0
Source dataset
uspto-grants-1978_08
Patent number
US04110464

Reaction notes

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