Hydrochloric Acid → HCID 118963265, compound

Participants

Reaction Steps

22.1 g. of α-ethyl-3,5-di-iodo thyronine are dissolved in 130 cc. of a 33% solution of ethylamine in water and 86.5 cc. of a 1.85 N solution of potassium iodide and iodine are added drop by drop to the above described solution while stirring. Stirring is continued for one more hour and 16% hydrochloric acid is added in an amount sufficient to adjust the pH value to a pH of 5.0. The precipitate is filtered off, washed with water, and dissolved in 250 cc. of ethanol with the addition of 100 cc. of 2 N sodium hydroxide solution. The solution is purified by means of charcoal and is acidified with 2 N hydrochloric acid to a pH of 6.0. α-Ethyl thyroxine, melting at 236°-238° C. is obtained in a yield of 60% of the theoretical yield.

Provenance & Evidence