Methyl iodide → HCID 58246335, compound

Participants

Reaction Steps

Butane-1-sulfonic acid (2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-1,2,3,4-tetrahydro-isoquinolin-7-yloxy}-ethyl)-amide hydrochloride (example 16, 50.0 mg, 0.10 mmol) is dissolved in acetone (3 ml) and potassium carbonate (29.0 mg, 0.21 mmol) and methyl iodide (16.4 mg, 0.12 mmol) were added. The mixture was stirred at RT for 14 h. The sol-vent was reduced, the reaction mixture was diluted with 1 N sodium hydroxid solution and extracted with dichloromethane. The combined organic layers were washed with saturated sodium chloride solution and dried with potassium sulphate. The residue was purified by HPLC with . . . to give the product (50.0 mg, 0.10 mmol, 13%).

Provenance & Evidence