HCID 13065269, compound → HCID 20311656, compound

HRID 2420471Notes

Reaction equation

HRID 2420471 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][NH:17][CH2:18][CH2:19][CH:20]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][NH:17][CH2:18][CH2:19][CH:20]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 13065269HCID 13065269, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20311656HCID 20311656, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The starting material is prepared as follows: The mixture of 7.5 g of N-[2-(4-benzyloxyphenyl)-ethyl]-3,3-diphenylpropylamine, 125 ml of ethanol and 0.25 g of 10% palladium on charcoal is shaken under 3 atmospheres of hydrogen for 20 hours. 4.5 g of fresh catalyst are added and hydrogenolysis continued at 3 atmospheres for 70 hours. The mixture is filtered and evaporated to afford the N-[2-(4-hydroxyphenyl)-ethyl]-3,3-diphenylpropylamine of sufficient purity.

Workup

  1. customThe starting material is prepared
  2. filtrationThe mixture is filtered
  3. customevaporated

Sources & evidence

ORD record
ord-72cd2d57a7fb45a896fe642192a32910
Source dataset
uspto-grants-1978_08
Patent number
US04110457

Reaction notes

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