Dimethylamine → HCID 20335705, compound

HRID 2420481Notes

Reaction equation

HRID 2420481 reaction equation
[O:1]=[C:2]1[N:6]2[C:7]3[CH:22]=[CH:21][C:20](Cl)=[N:19][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])=[N:10][CH2:11][C:5]2=[N:4][NH:3]1.[CH3:24][NH:25][CH3:26]>C(O)C>[O:1]=[C:2]1[N:6]2[C:7]3[CH:22]=[CH:21][C:20]([N:25]([CH3:26])[CH3:24])=[N:19][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])=[N:10][CH2:11][C:5]2=[N:4][NH:3]1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 20335792HCID 20335792, compound

Product 1

HCID 20335705HCID 20335705, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 19 grams of 1-keto-6-(o-chlorophenyl)-8-chloro-1,2-dihydro-4H-s-triazolo-(4,3-a)-pyrido-(2,3-f)-(1,4)-diazepine, 80 grams of dimethylamine and 500 ml. of ethanol were heated in the autoclave for 8 hours at 100°-110° C. The solution was evaporated to dryness, the residue stirred with water, filtered off with suction and washed several times with water. Then it was recrystallized from methanol. Yield 8 grams; M.P. 244°-246° C.

Workup

  1. customThe solution was evaporated to dryness
  2. filtrationfiltered off with suction
  3. washwashed several times with water
  4. customThen it was recrystallized from methanol

Sources & evidence

ORD record
ord-acc05a14c2a04be6b2cd9ffa1cd290c2
Source dataset
uspto-grants-1978_08
Patent number
US04110455

Reaction notes

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