Chlorobenzene → 4-(4-Chlorobenzoyl)piperidine hydrochloride

HRID 2420495Notes

Reaction equation

HRID 2420495 reaction equation
C([N:4]1[CH2:12][CH2:11][CH:7]([C:8]([Cl:10])=[O:9])[CH2:6][CH2:5]1)(=O)C.[Cl-].[Al+3].[Cl-].[Cl-].[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[ClH:10].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:8]([CH:7]2[CH2:6][CH2:5][NH:4][CH2:12][CH2:11]2)=[O:9])=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 7964ChlorobenzeneHCID 1009501-Acetylpiperidine-4-carbonyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 27771144-(4-Chlorobenzoyl)piperidine hydrochloride

Procedure

By following the manipulative procedures described above in Example 1(c), and (d), 37.4 g of 1-acetylisonipecotoyl chloride, [Example 1(b)] and 40 g of aluminum chloride in 90 ml of chlorobenzene are reacted to produce 4-(4-chlorobenzoyl)piperidine hydrochloride, The salt is recrystallized thrice from an ethanol-ether mixture to give a white product, mp 233°-235° C.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-e97902b4db9a4092974b8af1946f7d34
Source dataset
uspto-grants-1978_08
Patent number
US04110459

Reaction notes

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