HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(2-Bromoethyl)indole | HCID 76924 | — |
| Reactant | Phenyl(piperidin-4-yl)methanone | HCID 226102 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Indole | HCID 798 | — |
Reaction Steps
A solution of 10.4 g of 4-(benzoyl)piperidine, 6.1 g of triethylamine and 11.2 g of 3-(2-bromoethyl)indole in 350 ml of dimethylformamide is stirred at ambient temperature for 16 hours. Water is added dropwise, precipitating an off-white solid. The solid is collected, washed with water and low boiling petroleum ether, and dried. The solid is recrystallized from 95% ethanol to give white flakes, mp [145°-147° C., of 3-]2-(4-benzoylpiperidyl)ethyl]indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04110459 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-316d0639a43041ebac7d9bf02f681a8b |
| Source note | uspto-grants-1978_08 |