Phenyl chloroformate → HCID 13180319, compound

Participants

Reaction Steps

47.0 g of phenylchloroformate are added to a stirring solution of 57.5 g of 4-(2-fluorobenzoyl)-1-methyl piperidine in 750 ml of toluene. The reaction mixture is refluxed for 5 hours, cooled to ambient temperature, filtered, and the solvent is removed leaving a light colored oil. Theoil is triturated with hexane to give a crystalline material which is recrystallized twice from an ethanol-water mixture and once from ethanol The oil give the compound, mp 95°-96° C., 1-phenoxycarbonyl-4-(2-fluorobenzoyl)piperidine.

Provenance & Evidence