Water → HCID 13180293, compound

Participants

Reaction Steps

A solution of 9.1 g of 3-(2-bromoethyl)indole in 100 ml of dimethyl formamide is added to a stirring solution of 11.2 g of 4-(2-fluorobenzoyl)piperidine hydrochloride and 13 g of potassium carbonate in 400 ml of dimethylformamide. The reaction mixture is stirred at ambient temperature for 24 hours, and then 800 ml of water are added dropwise, yielding a dark precipitate. This mixture is again stirred at ambient temperature for 24 hours and filtered to give a yellow crystalline material which is recrystallized thrice from an ehtanol-water mixture to give an off-white crystalline material, mp 106°-108° C. , 3-{2-[4-(2-fluorobenzoyl)piperidyl]-ethyl}indole.

Provenance & Evidence