Hydrochloric Acid → HCID 20312104, compound

Participants

Reaction Steps

A mixture of 5-chlorotryptophan (32 g, 0.14 mole) and potassium cyanate (22.6 g, 0.28 mole) in 500 ml of H2O was heated on the steam bath for 3 hours, cooled and acidified with concentrated HCl. The solid was collected, suspended in 500 ml of 10% HCl and heated on the steam bath for 2 hours. The solid, obtained on cooling, was dissolved in dilute NaOH, filtered and acidified with dilute HCl. The solid obtained was recrystallized from aqueous 2-PrOH. Yield 17 g (37.6%), m.p. 226°-8°, contains a mole of 2-PrOH.

Provenance & Evidence