Triethylamine → L-Leucine

Participants

Reaction Conditions

Reaction Steps

The Merrifield resin (2.1 g) was suspended in 30 ml of ethanol. A solution of 0.70 g (2.71 mM) of Boc-Leu and 0.9 equivalent of Et3N (2.43 mM, 0.34 ml) in 3 ml of ethanol was added to the resin suspension. The mixture was stirred slowly at 90° C. under anhydrous conditions for 24 hours using a magnetic stirrer. The esterified resin was washed successively with EtOH, H2O, MeOH and CH2Cl2 ; floated 3 times with CH2Cl2 to get rid of fine resin particles; and dried in vacuo over P2O5. Amino acid analysis gave a value of 0.25 mM of Leu/g of substituted resin.

Provenance & Evidence