Sodium periodate → 8-Ethyl-2-methylsulfinyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one
Reaction equation
[CH2:1]([N:3]1[C:7]2[N:8]=[CH:9][C:10]3[C:11](=[O:21])[NH:12][C:13]4[N:14]([N:16]=[C:17]([S:19][CH3:20])[N:18]=4)[C:15]=3[C:6]=2[CH:5]=[N:4]1)[CH3:2].I([O-])(=O)(=O)=[O:23].[Na+]>>[CH2:1]([N:3]1[C:7]2[N:8]=[CH:9][C:10]3[C:11](=[O:21])[NH:12][C:13]4[N:14]([N:16]=[C:17]([S:19]([CH3:20])=[O:23])[N:18]=4)[C:15]=3[C:6]=2[CH:5]=[N:4]1)[CH3:2]Participants
3
Procedure
3.01 g. of 8-ethyl-2-methylthio-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one obtained in Example 10 (a) are oxidized with 2.2 g. of sodium metaperiodate in aqueous alcohol for 7 days at room temperature. The precipitate of 8-ethyl-2-methylsulfinyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one is filtered off, washed with water and recrystallized from dimethylformamide, yield 2.8 g. (88%); m.p. > 300°.
Workup
- filtrationThe precipitate of 8-ethyl-2-methylsulfinyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one is filtered off
- washwashed with water
- customrecrystallized from dimethylformamide, yield 2.8 g
Sources & evidence
- ORD record
- ord-d7c4695b68d94bb1a42fd7fdb04717b7
- Source dataset
- uspto-grants-1978_08
- Patent number
- US04110454
Reaction notes
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