1-(4-Fluorophenyl)cyclobutanecarboxylic acid → 1-[1-(4-Fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-ol

HRID 242058Notes

Reaction equation

HRID 242058 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([OH:22])[CH:20]=4)[CH2:15][CH2:14][N:13]=3)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[F:23]C1C=CC(C2(C(O)=O)CCC2)=CC=1>>[F:23][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([OH:22])[CH:20]=4)[CH2:15][CH2:14][N:13]=3)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 167690171-(4-Fluorophenyl)cyclobutanecarboxylic acidHCID 582462431-[1-(4-Chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-ol

Product 1

HCID 582463501-[1-(4-Fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-ol

Procedure

The compound was prepared analogously to 1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-ol (cf. example 82) starting from 1-(4-fluorophenyl)cyclobutanecarboxylic acid.

Sources & evidence

ORD record
ord-5d3e20bf767f4c64a8e1eafa96c3af9d
Source dataset
uspto-grants-2014_02
Patent number
US08653100B2

Reaction notes

Loading…