化工社化工社 化学情報印刷レポート · 研究参考用
N,N-Dimethyl-1,3-propanediamine → 2-Ethyl-8-isopropyl-5-morpholino-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Dimethyl-1,3-propanediamine | HCID 7993 | — |
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester | HCID 162357 | — |
| 反応物 | 1-isopropyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester | HCID 428334 | — |
| 反応物 | Methanimidic acid, N-cyano-, ethyl ester | HCID 9920370 | — |
| 反応物 | ethyl N-cyanopropionimidate | HCID 10820532 | — |
| 反応物 | 5-chloro-2-ethyl-8-isopropyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine | HCID 22758508 | — |
| 反応物 | 8-ethyl-2-methylthio-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one | HCID 135593862 | — |
| 生成物 | 2-Ethyl-8-isopropyl-5-morpholino-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine | HCID 22758539 | — |
反応手順
By substituting 1-isopropyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester for the 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester and 1-ethoxypropylidene cyanamide for the ethoxymethylene cyanamide in part (a) and morpholine for the 3-dimethylaminopropylamine in part (c) of the procedure of Example 1,2-ethyl-8-isopropyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4-]triazolo[1,5-a]pyrimidin5(8H)-one, 5-chloro-2-ethyl-8-isopropyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine and 2-ethyl-8-isopropyl-5-morpholino-8H-pyrazolo[4',3':5,6]pyrido[3,4e][1,2,4]triazolo[1,5-a]pyrimidine, respectively, are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04110454 |
| 出典データセット | uspto-grants-1978_08 |
| ORD ID | ord-091868ab1e7a4c828d995eeb601dc228 |
| 出典メモ | uspto-grants-1978_08 |