HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester → 8-Benzyl-N-(1-methylpropyl)-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester | HCID 162357 | — |
| Reactant | 1-benzyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester | HCID 21823959 | — |
| Reactant | 5-Chloro-8-ethyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]-triazolo[1,5-a]pyrimidine | HCID 22758486 | — |
| Reactant | 8-benzyl-5-chloro-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine | HCID 22758538 | — |
| Reactant | 8-benzyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one | HCID 135593855 | — |
| Reactant | 8-ethyl-2-methylthio-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one | HCID 135593862 | — |
| Product | 8-Benzyl-N-(1-methylpropyl)-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5-amine | HCID 22758483 | — |
Reaction Steps
By substituting 1-benzyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester for the 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester in the procedure of Example 1 (a), (b) then proceeding as in Example 2, 8-benzyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one and 8-benzyl-5-chloro-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine and 8-benzyl-N-(1-methylpropyl)-8H-pyrazolo[4',3':5,6]pyrido[3,4e][1,2,4]triazolo[1,5-a]pyrimidin-5-amine, respectively, are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04110454 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-f8dc1b1f2fe246e3a5fbde314964fbd7 |
| Source note | uspto-grants-1978_08 |