Hydrochloric Acid → HCID 131711218, compound

Participants

Reaction Steps

A solution of 27.5 g of 3-(4'-chloro-4-biphenylyl)butyramide [m.p. 185° - 187°; obtainable from p-chlorobiphenyl via 4-acetyl-4'-chlorobiphenyl (m.p. 100° - 103°), 3-(4'-chloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester (m.p. 72°-74°) and 3-(4'-chloro-4-biphenylyl)-butyric acid (m.p. 154°-156°)] in 300 ml of THF is added dropwise, while stirring, to a solution of 4.6 g of diborane in 50 ml of THF, and the mixture is boiled for two hours, cooled and treated with 25% hydrochloric acid. It is then poured into water and worked up with sodium hydroxide solution and ethyl acetate to give 3-(4'-chloro-4-biphenylyl)-butylamine. Hydrochloride, m.p. 256°-259°.

Provenance & Evidence