Isopropylamine → HCID 70595162, compound

Participants

Reaction Steps

A solution of 2.22 g of 3-p-biphenylyl-2-buten-1-al (obtainable by reacting 4-acetylbiphenyl with 2,2-diethoxy-ethylmagnesium bromide and subsequent treatment with p-toluenesulfonic acid) and 0.6 g of isopropylamine in 25 ml of methanol is heated at 200° for 5 hours in a tube. After cooling, 0.5 g of Raney nickel, moist with methanol, is added and the resulting Schiff's base is hydrogenated for one hour at 100 atms. and 80°. The mixture is cooled and filtered and 1-isopropylamino-3-p-biphenylyl-butane is obtained.

Provenance & Evidence