Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methoxyphenol | HCID 9015 | — |
| Reactant | Dabco | HCID 9237 | — |
| Reactant | 3,5-difluoro-2-hydroxybenzaldehyde | HCID 2779374 | — |
| Solvent | Acrylonitrile | HCID 7855 | — |
| Product | HCID 59288362 | HCID 59288362 | — |
Reaction Steps
84 g (0.531 mol) of 3,5-difluorosalicylaldehyde are dissolved in 850 ml of acrylonitrile, 1 g (8 mmol) of p-methoxyphenol and 18 g (0.16 mol) of DABCO are added, and the mixture is heated overnight at 75° C. The batch is evaporated, the residue is taken up in dichloromethane, and the solution is filtered through silica gel, giving 6,8-difluoro-2H-chromene-3-carbonitrile, which is sufficiently pure for further reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07955664B2 |
|---|
| Source dataset | uspto-grants-2011_06 |
|---|
| ORD ID | ord-5d79a87995874f61a28cd05da4597ee0 |
|---|
| Source note | uspto-grants-2011_06 |
|---|
