反应详情

11.1 g (44.3 mmol) of 6-fluoro-3-pentylchroman-7-carbaldehyde are dissolved in 100 ml of ethanol, and 2.0 g (52.8 mmol) of sodium borohydride are added in portions. After 3 h, the batch is diluted with water and extracted three times with MTB ether. The combined org. phases are washed with sat. sodium chloride soln. and dried over sodium sulfate, the solvent is removed in vacuo, and the residue is filtered through silica gel with dichloromethane (Rf=0.3), giving (6-fluoro-3-pentylchroman-7-yl)methanol as a colourless solid.

1. extractionextracted three times with MTB ether
2. washphases are washed with sat. sodium chloride soln
3. dry with materialand dried over sodium sulfate
4. customthe solvent is removed in vacuo
5. filtrationthe residue is filtered through silica gel with dichloromethane (Rf=0.3)