4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → HCID 67214970, compound

HRID 2420697Notes

Reaction equation

HRID 2420697 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:6][CH:7]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[C:25]([C:28](O)=[O:29])[NH:26][CH:27]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[C:25]([C:28]([NH:1][C:2]3[CH:7]=[N:6][C:5]([O:8][CH2:9][CH2:10][N:11]4[CH2:15][CH2:14][CH2:13][CH2:12]4)=[CH:4][CH:3]=3)=[O:29])[NH:26][CH:27]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 128970994-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acidHCID 58236672HCID 58236672, compound

Product 1

HCID 67214970HCID 67214970, compound

Procedure

5-Amino-2-((pyrrolidin-1-yl)ethoxy)pyridine was converted to the title compound (18 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid (21 mg) following the procedure described in step C of Example 1. MS (ESI) 411 (M+H)+.

Sources & evidence

ORD record
ord-7a737016fe0a4254801471fca8dcc8b3
Source dataset
uspto-grants-2011_06
Patent number
US07956049B2

Reaction notes

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