HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → 4-(4-chlorophenyl)-N-(3-methoxy-4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid | HCID 12897099 | — |
| Reactant | 2-(4-Amino-2-methoxyphenoxy)-1-(pyrrolidin-1-yl)ethanone | HCID 55036873 | — |
| Product | 4-(4-chlorophenyl)-N-(3-methoxy-4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrole-2-carboxamide | HCID 67215262 | 95% |
Reaction Steps
Acylation of 2-(4-amino-2-methoxyphenoxy)-1-(pyrrolidin-1-yl)ethanone with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid to generate the title compound was achieved following the procedure described in step C of Example 1 in 95% yield. MS (ESI) 401 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07956049B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-b365e0eb3c19462295d601ac09e52780 |
| Source note | uspto-grants-2011_06 |