4-(2-(Pyrrolidin-1-yl)ethoxy)aniline → HCID 67215144, compound

HRID 2420705Notes

Reaction equation

HRID 2420705 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[C:25]([C:28](O)=[O:29])[NH:26][CH:27]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[C:25]([C:28]([NH:15][C:12]3[CH:11]=[CH:10][C:9]([O:8][CH2:7][CH2:6][N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)=[CH:14][CH:13]=3)=[O:29])[NH:26][CH:27]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 64937494-(2-(Pyrrolidin-1-yl)ethoxy)anilineHCID 128970994-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid

Product 1

HCID 67215144HCID 67215144, compoundYield 56.2%

Procedure

4-(2-(Pyrrolidin-1-yl)ethoxy)benzenamine (35 mg) from step A was converted to the title compound (26 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid (25 mg) following the procedure described in step C of Example 1. Step C. MS (ESI) 410 (M+H)+.

Sources & evidence

ORD record
ord-ebb2f463262641e0b5cc1a2ce53f5db7
Source dataset
uspto-grants-2011_06
Patent number
US07956049B2

Reaction notes

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